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KMID : 0378119900170010189
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Chungnam Medical Journal
1990 Volume.17 No. 1 p.189 ~ p.194
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Vincristine, Bleomycin, Mitomycin-C, Cisplatin Combination Therapy in Patients with Advanced or Recurrent Cervical Cancer
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Abstract
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Seventeen patients with advanced or recurrent cervical cancer were treated with vincristine, bleomycin, mitomyicin-C and cisplatin between February, 1986 and January, 1989.
l. Among evaluable patients, response rate was 55.6％(patial responses in all). Response rates of advanced and recurrent group were 71％ and 0％, respectively.
2. Median survival for responders and nonresponders wrer 26 months and 25 months； there was no statistically significant differece (p>0.05).
3. Median survival for preoperative or preradiational chemotherapy and postoperative chemotherapy were 26 months and 23 months (p>0.05).
4. Nausea and vomiting were observed in most patients (88％), but easily controlled, and were followed in frequency by ferer, alopecia, leukopenia, stomatitis, diarrhea, but there was no serious toxicities
In conclusion, combination chemotherapy with vincristine, bleomycin, mitomycin-C and cisplatin in patients with advanced cervical vancer seemed to be relatively effective and well tolerable, but more cases need to be evaluated in patients with recurrent cervical cancer.
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KEYWORD
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